产品概述：Purified recombinant protein of Human renin (REN), 131Asp-End, with N-terminal HIS tag, expressed in E.Coli, 50 ug

蛋白长度：A DNA sequence encoding the region( 131Asp-End) of REN

表达系统：E. coli

种属：Human

标签类型：N-HIS

分子量：30.2KDa

通用名：REN

总结：This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis. [provided by RefSeq, May 2020]

形式：Liquid

浓度：>50 ug/mL as determined by microplate BCA method

纯度：> 85% as determined by SDS-PAGE and Coomassie blue staining

储存溶液：25 mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

别名：ADTKD4; HNFJ2; RTD