PHF1 monoclonal antibody (M01), clone 2D3
产品名称： PHF1 monoclonal antibody (M01), clone 2D3
英文名称： PHF1 monoclonal antibody (M01), clone 2D3
产品编号： H00005252-M01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant PHF1.
- Immunogen:
- PHF1 (NP_077084, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- AQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVP
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG1 Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
- MSDS:
Download
- Publication Reference
- 1.
- Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms.
Wang Y, Cheng Z, Qin W, Jia J.J Neurochem. 2012 Apr;121(1):135-45. doi: 10.1111/j.1471-4159.2011.07489.x. Epub 2012 Feb 10.
- 2.
- A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.
Hong Z, Jiang J, Lan L, Nakajima S, Kanno SI, Koseki H, Yasui A.Nucleic Acids Res. 2008 May;36(9):2939-47. Epub 2008 Apr 1.
- 3.
- Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS.J Neurosci. 2007 Jun 27;27(26):7011-20.
- Applications
- Western Blot (Cell lysate)
- PHF1 monoclonal antibody (M01), clone 2D3 Western Blot analysis of PHF1 expression in A-431 ( Cat # L015V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Entrez GeneID:
- 5252
- GeneBank Accession#:
- NM_024165
- Protein Accession#:
- NP_077084
- Gene Name:
- PHF1
- Gene Alias:
- MTF2L2,PCL1,PHF2
- Gene Description:
- PHD finger protein 1
- Omim ID:
- 602881
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000029139,OTTHUMP00000029140